Early protein energy malnutrition impacts life-long developmental trajectories of the sources of EEG rhythmic activity

Jorge Bosch-Bayard; Fuleah Abdul Razzaq; Carlos Lopez-Naranjo; Ying Wang; Min Li; Lidice Galan-Garcia; Ana Calzada-Reyes; Trinidad Virues-Alba; Arielle G Rabinowitz; Carlos Suarez-Murias; Yanbo Guo; Manuel Sanchez-Castillo; Kassandra Roger; Anne Gallagher; Leslie Prichep; Simon G Anderson; Christoph M Michel; Alan C Evans; Maria L Bringas-Vega; Janina R Galler; Pedro A Valdes-Sosa

doi:10.1016/j.neuroimage.2022.119144

Early protein energy malnutrition impacts life-long developmental trajectories of the sources of EEG rhythmic activity

Neuroimage. 2022 Jul 1:254:119144. doi: 10.1016/j.neuroimage.2022.119144. Epub 2022 Mar 24.

Authors

Jorge Bosch-Bayard¹, Fuleah Abdul Razzaq², Carlos Lopez-Naranjo³, Ying Wang³, Min Li³, Lidice Galan-Garcia⁴, Ana Calzada-Reyes⁴, Trinidad Virues-Alba⁴, Arielle G Rabinowitz⁵, Carlos Suarez-Murias⁴, Yanbo Guo³, Manuel Sanchez-Castillo⁴, Kassandra Roger⁶, Anne Gallagher⁶, Leslie Prichep⁷, Simon G Anderson⁸, Christoph M Michel⁹, Alan C Evans¹⁰, Maria L Bringas-Vega¹¹, Janina R Galler¹², Pedro A Valdes-Sosa¹³

Affiliations

¹ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; McGill Center for Integrative Neuroscience Center MCIN. Ludmer Center for Mental Health. Montreal Neurological Institute, McGill University, Montreal, Canada.
² The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: fuleah.razzaq@outlook.com.
³ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.
⁴ Cuban Neuroscience Center, La Habana, Cuba.
⁵ Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
⁶ LION Lab, Sainte-Justine University Hospital Research Centre, University of Montreal, Montreal, QC, Canada.
⁷ Brain Research Laboratories, New York University, USA.
⁸ Caribbean Institute for Health Research, University of the West Indies, Barbados.
⁹ Department of Basic Neurosciences, University of Geneva, Switzerland.
¹⁰ McGill Center for Integrative Neuroscience Center MCIN. Ludmer Center for Mental Health. Montreal Neurological Institute, McGill University, Montreal, Canada.
¹¹ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; Cuban Neuroscience Center, La Habana, Cuba.
¹² Division of Pediatric Gastroenterology and Nutrition, Mucosal Immunology and Biology Research Center, Mass General Hospital for Children, Boston, MA, USA.
¹³ The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China; McGill Center for Integrative Neuroscience Center MCIN. Ludmer Center for Mental Health. Montreal Neurological Institute, McGill University, Montreal, Canada; Cuban Neuroscience Center, La Habana, Cuba. Electronic address: pedro.valdes@neuroinformatics-collaboratory.org.

PMID: 35342003
DOI: 10.1016/j.neuroimage.2022.119144

Abstract

Protein Energy Malnutrition (PEM) has lifelong consequences on brain development and cognitive function. We studied the lifelong developmental trajectories of resting-state EEG source activity in 66 individuals with histories of Protein Energy Malnutrition (PEM) limited to the first year of life and in 83 matched classmate controls (CON) who are all participants of the 49 years longitudinal Barbados Nutrition Study (BNS). qEEGt source z-spectra measured deviation from normative values of EEG rhythmic activity sources at 5-11 years of age and 40 years later at 45-51 years of age. The PEM group showed qEEGt abnormalities in childhood, including a developmental delay in alpha rhythm maturation and an insufficient decrease in beta activity. These profiles may be correlated with accelerated cognitive decline.

Keywords: EEG; Longitudinal study; Malnutrition; Source analysis; Tomography; qEEG.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Cognitive Dysfunction*
Electroencephalography
Humans
Longitudinal Studies
Nutritional Status
Protein-Energy Malnutrition*