Two cationic meso-thiophenium porphyrins and their zinc-complexes as anti-HIV-1 and antibacterial agents under non-photodynamic therapy (PDT) conditions

Abstract

The anti-HIV-1 and antimicrobial activities of novel cationic meso-thiophenium porphyrins and their zinc-complex are reported under in vitro non-photodynamic (PDT) conditions. While all the cationic porphyrins led to the inhibition of de novo virus infection, the Zn(II)-complexes of T₂(OH)₂M (A₂B₂-type) and T(OH)₃M (AB₃-type) displayed potent inhibition of HIV-1 entry with T₂(OH)₂MZn displaying maximal anti-HIV activity. The Zinc complex of both the thiophenium porphyrins T₂(OH)₂M and T(OH)₃M also depicted antibacterial activities against Escherichia coli (ATCC 25922) and more prominently against Staphylococcus aureus (ATCC 25923). Again, the antibacterial activity was more potent for T₂(OH)₂MZn. Our study highlighted that the presence of two thiophenium groups at the meso-positions of the A₂B₂-type porphyrins along with zinc strongly enhanced anti-HIV and antimicrobial properties of these novel thiophenium porphyrins under non-PDT conditions.

Keywords: Anti-HIV; Anti-microbial; Bactericidal; Thiophenium porphyrins; Zn-porphyrins.