Abstract
Phenolic compounds derived from olive oil have beneficial health properties against cancer, neurodegenerative, and metabolic diseases. Therefore, there are discrepancies in their impact on mitochondrial function that result in changes in oxidative capacity, mitochondrial respiration, and energetic demands. This review focuses on the versatile role of oleuropein, a potent antioxidant that regulates the AMPK/SIRT1/mTOR pathway to modulate autophagy/mitophagy and maintain metabolic homeostasis.
Keywords:
Antioxidants; Mediterranean diet; cell death; hydroxytyrosol; mitophagy; oleuropein.
© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.
Grants and funding
This research was supported by the “Instituto de Salud Carlos” III CIBERNED [CB06/05/0041] and partially supported by the “Fondo Europeo de Desarrollo Regional” (FEDER) from the European Union. M. B-B was supported by a collaboration grant from the Ministerio de Educación y Formación Profesional, Spain. A. C-F is supported by a grant (IB20031 from the Junta de Extremadura, Spain. S. C-C and E.U-C are supported by a FPU fellowship [FPU19/04435 and FPU16/00684, respectively] from the Ministerio de Ciencia, Innovación y Universidades, Spain. M. P-B and A.G-B are recipients of fellowships from the “Plan Propio de Iniciación a la Investigación, Desarrollo Tecnológico e Innovación (University of Extremadura). E. A-C is supported by a pre-doctoral fellowship of Valhondo Calaff Foundation. G. M-C was supported by University of Extremadura (ONCE Foundation). G. D-G is supported by the Consejería de Educación y Empleo-SEXPE-Fondo Social Europeo [TE-0031-19]. P. G-S, was funded by “Juan de la Cierva Incorporación” Program [IJC2019-039229-I], Spain. M.N-S was funded by the “Ramon y Cajal” Program [RYC-2016–20883], Spain. S.M.S.Y-D was supported by CIBERNED [CB06/05/0041].