The history of Salpingoeca rosetta as a model for reconstructing animal origins

David S Booth; Nicole King

doi:10.1016/bs.ctdb.2022.01.001

The history of Salpingoeca rosetta as a model for reconstructing animal origins

Curr Top Dev Biol. 2022:147:73-91. doi: 10.1016/bs.ctdb.2022.01.001. Epub 2022 Mar 11.

Authors

David S Booth¹, Nicole King²

Affiliations

¹ Chan Zuckerberg Biohub and Department of Biochemistry and Biophysics, University of California, San Francisco, CA, United States. Electronic address: David.Booth@ucsf.edu.
² Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States. Electronic address: nking@berkeley.edu.

PMID: 35337467
DOI: 10.1016/bs.ctdb.2022.01.001

Abstract

Choanoflagellates, the closest living relatives of animals, have the potential to reveal the genetic and cell biological foundations of complex multicellular development in animals. Here we describe the history of research on the choanoflagellate Salpingoeca rosetta. From its original isolation in 2000 to the establishment of CRISPR-mediated genome editing in 2020, S. rosetta provides an instructive case study in the establishment of a new model organism.

Keywords: Animal origins; Choanoflagellates; Electroporation; Genome editing; Multicellularity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Choanoflagellata* / genetics
Developmental Biology