Improved Method for Preparation of 3-(1 H-Indol-3-yl)benzofuran-2(3 H)-ones

Igor Yu Grishin; Nikolai A Arutiunov; Dmitrii A Aksenov; Nicolai A Aksenov; Alexander V Aksenov; Amina Z Gasanova; Elena A Sorokina; Carolyn Lower; Michael Rubin

doi:10.3390/molecules27061902

Improved Method for Preparation of 3-(1 H-Indol-3-yl)benzofuran-2(3 H)-ones

Molecules. 2022 Mar 15;27(6):1902. doi: 10.3390/molecules27061902.

Authors

Igor Yu Grishin¹, Nikolai A Arutiunov¹, Dmitrii A Aksenov¹, Nicolai A Aksenov¹, Alexander V Aksenov¹, Amina Z Gasanova¹, Elena A Sorokina², Carolyn Lower³, Michael Rubin^{1

3}

Affiliations

¹ Department of Chemistry and Pharmacy, North Caucasus Federal University, 1a Pushkin St., 355017 Stavropol, Russia.
² Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
³ Department of Chemistry, University of Kansas, 1567 Irving Hill Road, Lawrence, KS 66045, USA.

Abstract

3-(1H-Indol-3-yl)benzofuran-2(3H)-ones were efficiently accessed via polyphosphoric acid-mediated condensation of 3-(2-nitrovinyl)-1H-indoles with phenols.

Keywords: Brønsted acid catalysis; cascade transformations; indoles; nitroalkanes; rearrangements.

Improved Method for Preparation of 3-(1 H-Indol-3-yl)benzofuran-2(3 H)-ones

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