Voltammetric Determination of Isoniazid in the Presence of Acetaminophen Utilizing MoS2-Nanosheet-Modified Screen-Printed Electrode

Somayeh Tajik; Zahra Dourandish; Fariba Garkani Nejad; Abbas Aghaei Afshar; Hadi Beitollahi

doi:10.3390/mi13030369

Voltammetric Determination of Isoniazid in the Presence of Acetaminophen Utilizing MoS₂-Nanosheet-Modified Screen-Printed Electrode

Micromachines (Basel). 2022 Feb 26;13(3):369. doi: 10.3390/mi13030369.

Authors

Somayeh Tajik¹, Zahra Dourandish², Fariba Garkani Nejad², Abbas Aghaei Afshar¹, Hadi Beitollahi²

Affiliations

¹ Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman 7616913555, Iran.
² Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman 7631885356, Iran.

Abstract

We used MoS₂ nanosheets (MoS₂ NSs) for surface modification of screen-printed electrode (MoS₂NSs-SPE) aimed at detecting isoniazid (INZ) in the presence of acetaminophen (AC). According to analysis, an impressive catalytic performance was found for INZ and AC electro-oxidation, resulting in an appreciable peak resolution (~320 mV) for both analytes. Chronoamperometry, differential pulse voltammetry (DPV), linear sweep voltammogram (LSV), and cyclic voltammetry (CV) were employed to characterize the electrochemical behaviors of the modified electrode for the INZ detection. Under the optimal circumstances, there was a linear relationship between the peak current of oxidation and the various levels of INZ (0.035-390.0 µM), with a narrow limit of detection (10.0 nM). The applicability of the as-developed sensor was confirmed by determining the INZ and AC in tablets and urine specimens, with acceptable recoveries.

Keywords: MoS2 nanosheets; acetaminophen; isoniazid; modified electrode; voltammetric sensors.