Effect of Dietary Intake Through Whole Foods on Cognitive Function: Review of Randomized Controlled Trials

Curr Nutr Rep. 2022 Jun;11(2):146-160. doi: 10.1007/s13668-022-00412-5. Epub 2022 Mar 25.

Abstract

Purpose of review: This review evaluated recent randomized controlled trials (RCTs) examining the chronic intake of whole foods associated with the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), Mediterranean-DASH Intervention for Neurogenerative Delay (MIND), and ketogenic (KETO) diets on cognitive function.

Recent findings: We identified RCTs related to olive oil (N = 3), nuts (N = 7), fatty fish (N = 1), lean meats (N = 4), fruits and vegetables (N = 9), legumes (N = 1), and low-fat dairy (N = 4), with 26/29 reporting positive results on at least one measure of cognition. We also identified 6 RCTs related to whole food-induced KETO diets, with half reporting positive effects on cognition. Variations in study design (i.e., generally the studies are < 6 months and include middle-aged and older, cognitively intact participants) and small sample sizes make it difficult to draw conclusions across studies; however, the current evidence from RCTs generally supports individual component intakes of these dietary patterns as an effective, nonpharmacological approach to improve cognitive health in adults.

Keywords: Cognitive function; DASH diet; Ketogenic diet; MIND diet; Mediterranean diet; Whole foods.

Publication types

  • Review
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cognition
  • Diet, Mediterranean*
  • Dietary Approaches To Stop Hypertension*
  • Eating
  • Humans
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Vegetables