Research progress on epigenetics of small B-cell lymphoma

Xueqin Ruan; Rong Zhang; Hongkai Zhu; Can Ye; Zhihua Wang; En Dong; Ruijuan Li; Zhao Cheng; Hongling Peng

doi:10.1007/s12094-022-02820-z

Research progress on epigenetics of small B-cell lymphoma

Clin Transl Oncol. 2022 Aug;24(8):1501-1514. doi: 10.1007/s12094-022-02820-z. Epub 2022 Mar 25.

Authors

Xueqin Ruan^{1

2

3}, Rong Zhang⁴, Hongkai Zhu^{1

2

3}, Can Ye^{1

2

3}, Zhihua Wang^{1

2

3}, En Dong⁵, Ruijuan Li^{6

7

8}, Zhao Cheng^{9

10

11}, Hongling Peng^{1

2

3

12}

Affiliations

¹ Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Hunan Engineering Research Center of Targeted Therapy for Hematopoietic Malignancies, Changsha, Hunan, China.
³ Institute of Molecular Hematology, Central South University, Changsha, Hunan, China.
⁴ Division of Cancer Immunotherapy, National Cancer Center Exploratory Oncology Research & Clinical Trial Center, Chiba, Japan.
⁵ Blood Center, Changsha, Hunan, China.
⁶ Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. ruijuanli@csu.edu.cn.
⁷ Hunan Engineering Research Center of Targeted Therapy for Hematopoietic Malignancies, Changsha, Hunan, China. ruijuanli@csu.edu.cn.
⁸ Institute of Molecular Hematology, Central South University, Changsha, Hunan, China. ruijuanli@csu.edu.cn.
⁹ Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China. chengzhao@csu.edu.cn.
¹⁰ Hunan Engineering Research Center of Targeted Therapy for Hematopoietic Malignancies, Changsha, Hunan, China. chengzhao@csu.edu.cn.
¹¹ Institute of Molecular Hematology, Central South University, Changsha, Hunan, China. chengzhao@csu.edu.cn.
¹² Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

PMID: 35334078
DOI: 10.1007/s12094-022-02820-z

Abstract

Small B-cell lymphoma is the classification of B-cell chronic lymphoproliferative disorders that include chronic lymphocytic leukaemia/small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia. The clinical presentation is somewhat heterogeneous, and its occurrence and development mechanisms are not yet precise and may involve epigenetic changes. Epigenetic alterations mainly include DNA methylation, histone modification, and non-coding RNA, which are essential for genetic detection, early diagnosis, and assessment of treatment resistance in small B-cell lymphoma. As chronic lymphocytic leukemia/small lymphocytic lymphoma has already been reported in the literature, this article focuses on small B-cell lymphomas such as follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, and Waldenstrom macroglobulinemia. It discusses recent developments in epigenetic research to diagnose and treat this group of lymphomas. This review provides new ideas for the treatment and prognosis assessment of small B-cell lymphoma by exploring the connection between small B-cell lymphoma and epigenetics.

Keywords: DNA methylation; Epigenetics; Histone modification; Non-coding RNA; Small B-cell lymphoma.

Publication types

Review

MeSH terms

Adult
Epigenesis, Genetic
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Lymphoma, B-Cell, Marginal Zone* / diagnosis
Lymphoma, B-Cell, Marginal Zone* / genetics
Lymphoma, B-Cell, Marginal Zone* / pathology
Lymphoma, Follicular* / diagnosis
Lymphoma, Mantle-Cell* / diagnosis
Lymphoma, Mantle-Cell* / genetics
Lymphoma, Mantle-Cell* / pathology
Waldenstrom Macroglobulinemia* / diagnosis
Waldenstrom Macroglobulinemia* / genetics
Waldenstrom Macroglobulinemia* / pathology

Abstract

Publication types

MeSH terms

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