Shunt-type plexiform lesions identified in the Sugen5416/hypoxia rat model of pulmonary arterial hypertension using synchrotron-based phase-contrast micro-CT

Oscar van der Have; Christian Westöö; Filip Ahrné; Xuefei Tian; Kenzo Ichimura; Till Dreier; Christian Norvik; Maya E Kumar; Edda Spiekerkoetter; Karin Tran-Lundmark

doi:10.1183/13993003.02802-2021

Shunt-type plexiform lesions identified in the Sugen5416/hypoxia rat model of pulmonary arterial hypertension using synchrotron-based phase-contrast micro-CT

Eur Respir J. 2022 Jun 9;59(6):2102802. doi: 10.1183/13993003.02802-2021. Print 2022 Jun.

Authors

Oscar van der Have¹, Christian Westöö², Filip Ahrné³, Xuefei Tian^{4

5}, Kenzo Ichimura^{4

5}, Till Dreier⁶, Christian Norvik², Maya E Kumar^{5

7}, Edda Spiekerkoetter^{4

5

8}, Karin Tran-Lundmark^{2

3

9}

Affiliations

¹ Dept of Experimental Medical Science, Lund University, Lund, Sweden oscar.van_der_have@med.lu.se.
² Dept of Experimental Medical Science, Lund University, Lund, Sweden.
³ The Pediatric Heart Center, Skane University Hospital, Lund, Sweden.
⁴ Division of Pulmonary and Critical Care Medicine, Dept of Medicine, Stanford University, Stanford, CA, USA.
⁵ Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
⁶ Medical Radiation Physics, Dept of Clinical Sciences, Lund University, Lund, Sweden.
⁷ Division of Pulmonary Medicine, Dept of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
⁸ Cardiovascular Institute, Stanford University, Stanford, CA, USA.
⁹ Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.

Abstract

Human like plexiform lesions identified in the prolonged Sugen5416/hypoxia rat model, visualised by synchrotron tomography imaging https://bit.ly/3KQvDHg

Publication types

Letter
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Animals
Disease Models, Animal
Familial Primary Pulmonary Hypertension
Humans
Hypoxia
Pulmonary Arterial Hypertension*
Pulmonary Artery
Rats
Synchrotrons
X-Ray Microtomography

Abstract

Publication types

MeSH terms

Grants and funding