Roles of Syndecan-4 in cardiac injury and repair

Faheem Shaik; Michaela J M Balderstone; Samantha Arokiasamy; James R Whiteford

doi:10.1016/j.biocel.2022.106196

Roles of Syndecan-4 in cardiac injury and repair

Int J Biochem Cell Biol. 2022 May:146:106196. doi: 10.1016/j.biocel.2022.106196. Epub 2022 Mar 22.

Authors

Faheem Shaik¹, Michaela J M Balderstone¹, Samantha Arokiasamy², James R Whiteford³

Affiliations

¹ William Harvey Research Institute, Centre for Microvascular Research, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, UK.
² William Harvey Research Institute, Centre for Microvascular Research, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, UK. Electronic address: s.arokiasamy@ucl.ac.uk.
³ William Harvey Research Institute, Centre for Microvascular Research, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, EC1M 6BQ, UK. Electronic address: j.whiteford@qmul.ac.uk.

PMID: 35331918
DOI: 10.1016/j.biocel.2022.106196

Abstract

The heparan sulphate proteoglycan Syndecan-4 belongs to a 4-member family of transmembrane receptors. Genetic deletion of Syndecan-4 in mice causes negligible developmental abnormalities however when challenged these animals show distinct phenotypes. Synedcan-4 is expressed in many cell types in the heart and its expression is elevated in response to cardiac injury and recent studies have suggested roles for Syndecan-4 in repair mechanisms within the damaged heart. The purpose of this review is to explore these biological insights into the role of Syndecan-4 in both the injured heart and later during cardiac repair and remodeling.

Keywords: Angiogenesis; Cardiac fibrosis; Cardiac remodeling; Myocardial infarction; Syndecan.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Heart*
Mice
Syndecan-4* / genetics

Substances

Sdc4 protein, mouse
Syndecan-4