Effect of trait anxiety on cognitive flexibility: Evidence from event-related potentials and resting-state EEG

Abstract

Individuals with anxiety often exhibit cognitive flexibility impairment; however, the neural underpinnings of this cognitive impairment remain unclear. In this study, 45 participants were instructed to complete a task-switching assessment of shifting function by EEG technology, and 200 participants were included in microstate analysis to study why cognitive flexibility is impaired and the neuromechanism. Behaviorally, a positive correlation between trait anxiety scores and set shifting cost was found. At the EEG level, there was a positive correlation between trait anxiety scores and frontal P2 peaks under the shifting condition, which was related to the activation of the stimulus-response associations by attention. Furthermore, microstate analysis was used to analyze EEG functional networks, and TA scores had significant positive correlations with the Occurrence of class D and the Contribution of class D, which was related to the dorsal attention network. These results provided direct neuroelectrophysiological evidence that trait anxiety impairs cognitive flexibility when shifting is required.

Keywords: Cognitive flexibility; EEG; Frontal P2; Microstate class D; Trait anxiety.