Vein of Marshall Ethanol Infusion as First Step for Mitral Isthmus Linear Ablation

Abstract

Objectives: In this study, the authors sought to investigate the added value of vein of Marshall ethanol infusion (VOMEt) as first step in facilitating radiofrequency (RF)-guided mitral isthmus (MI) block.

Background: Achieving MI block with the use of RF ablation is challenging.

Methods: Seventy patients planned for MI ablation were randomized 1:1 to VOMEt as a first step preceding RF (endocardial and epicardial, VOM_FIRST group) vs RF ablation as a first step preceding VOMEt (RF_FIRST group). The study end point was incidence of MI block after RF ablation and after the 2 steps.

Results: In VOM_FIRST, VOMEt was successful in 30/35 patients (86%) resulting in a low-voltage area of 12 ± 7.4 cm² and MI block in 2/35 patients (6%). VOM_FIRST, compared with RF_FIRST, was associated with higher incidence of MI block after endocardial (46% vs 11%; P < 0.001) and epicardial ablation (94% vs 43%; P < 0.001), with fewer endocardial applications (4 vs 11 vs 4; P < 0.001) and similar epicardial applications (7 vs 8; P = 0.68). Incidence of MI block after the 2 steps was 94% vs 63% (P = 0.001) in VOM_FIRST vs RF_FIRST, respectively. Additional touch-up RF ablation in both groups resulted in final MI block in all but 1 patient (99%).

Conclusions: VOMEt as a first step in RF-guided MI line ablation significantly reduced the number of RF applications needed to achieve MI block, even if the sequence of the ablation steps did not affect the final incidence of block. (Evaluation of Vein of Marshall Ethanol Infusion During Left Atrial Linear Ablation in Patients With Persistent Atrial Fibrillation [MARSHALINE]; NCT04124328).

Keywords: mitral isthmus ablation; mitral isthmus block; radiofrequency ablation; vein of Marshall ethanol infusion.