Searching for a Link between Bone Decay and Diabetes Type 2

Endocr Metab Immune Disord Drug Targets. 2022;22(9):904-910. doi: 10.2174/1871530322666220324150327.

Abstract

The current commentary describes the possible existing link between metabolic diseases such as diabetes type 2 and the degenerative patterns of bones via the molecular mechanism that inhibits the mesenchymal stem cells' differentiation into osteoblasts and osteocytes.

Keywords: Diabetes type 1-2; ageing; bone decay; bone marrow (BM); central nervous system (CNS); enteric nervous system (ENS); mesenchymal stem cells (MSCs); osteoblasts; regenerative medicine.

MeSH terms

  • Bone Marrow Cells / metabolism
  • Cell Differentiation
  • Diabetes Mellitus, Type 2* / metabolism
  • Humans
  • Mesenchymal Stem Cells* / metabolism