The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response

Alexandra Daks; Elena Vasileva; Olga Fedorova; Oleg Shuvalov; Nickolai A Barlev

doi:10.3390/life12030362

The Role of Lysine Methyltransferase SET7/9 in Proliferation and Cell Stress Response

Life (Basel). 2022 Mar 2;12(3):362. doi: 10.3390/life12030362.

Authors

Alexandra Daks¹, Elena Vasileva^{1

2}, Olga Fedorova¹, Oleg Shuvalov¹, Nickolai A Barlev¹

Affiliations

¹ Institute of Cytology RAS, 194064 St. Petersburg, Russia.
² Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA 90027, USA.

Abstract

Lysine-specific methyltransferase 7 (KMT7) SET7/9, aka Set7, Set9, or SetD7, or KMT5 was discovered 20 years ago, yet its biological role remains rather enigmatic. In this review, we analyze the particularities of SET7/9 enzymatic activity and substrate specificity with respect to its biological importance, mostly focusing on its two well-characterized biological functions: cellular proliferation and stress response.

Keywords: SET7/9; SETD7; cell proliferation; lysine-specific methyltransferase (PKMT); post-translational protein modification; stress response.

Publication types

Review

Grants and funding

19-75-10059/Russian Science Foundation