Telomeric Repeat-Containing RNA (TERRA): A Review of the Literature and First Assessment in Cutaneous T-Cell Lymphomas

Alain Chebly; Joana Ropio; Lyla Baldasseroni; Martina Prochazkova-Carlotti; Yamina Idrissi; Jacky Ferrer; Chantal Farra; Marie Beylot-Barry; Jean-Philippe Merlio; Edith Chevret

doi:10.3390/genes13030539

Telomeric Repeat-Containing RNA (TERRA): A Review of the Literature and First Assessment in Cutaneous T-Cell Lymphomas

Genes (Basel). 2022 Mar 18;13(3):539. doi: 10.3390/genes13030539.

Authors

Alain Chebly^{1

2}, Joana Ropio^{1

3

4}, Lyla Baldasseroni¹, Martina Prochazkova-Carlotti¹, Yamina Idrissi¹, Jacky Ferrer¹, Chantal Farra^{2

5}, Marie Beylot-Barry^{1

6}, Jean-Philippe Merlio^{1

7}, Edith Chevret¹

Affiliations

¹ BoRdeaux Institute of Oncology (BRIC), UMR1312, INSERM, University of Bordeaux, 146 Rue Leo Saignat, 33076 Bordeaux, France.
² Medical Genetics Unit, Faculty of Medicine, Saint Joseph University, Beirut 1104 2020, Lebanon.
³ Institute of Biomedical Sciences of Abel Salazar, Porto University, 4050-313 Porto, Portugal.
⁴ Faculty of Veterinary Medicine, Lusófona University, 1749-024 Lisbon, Portugal.
⁵ Department of Genetics, Hotel Dieu de France Medical Center, Beirut 166830, Lebanon.
⁶ Department of Dermatology, Bordeaux University Hospital, 33075 Bordeaux, France.
⁷ Tumor Bank and Tumor Biology Laboratory, Bordeaux University Hospital, 33600 Pessac, France.

Abstract

Telomeric Repeat-containing RNA (TERRA) are long non-coding RNAs transcribed from telomeric DNA sequences from multiple chromosome ends. Major research efforts have been made to understand TERRA roles and functions in several physiological and pathological processes. We summarize herein available data regarding TERRA's roles in human cells and we report the first investigation in cutaneous T-cells lymphomas (CTCL) using real-time PCR. Among the TERRA analysed, our data suggest a particular role for TERRA 16p downregulation and TERRA 11q upregulation in CTCL lymphomagenesis.

Keywords: TERRA; cutaneous T-cell lymphomas; non-coding RNA; sézary syndrome; telomerase; telomere.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Down-Regulation
Humans
Lymphoma, T-Cell, Cutaneous* / genetics
RNA, Long Noncoding* / genetics
Telomere / genetics
Up-Regulation

Substances

RNA, Long Noncoding