Identification of Metabolism-Associated Biomarkers for Early and Precise Diagnosis of Oral Squamous Cell Carcinoma

Yuhan Wang; Xiaoxin Zhang; Shuai Wang; Zihui Li; Xinyang Hu; Xihu Yang; Yuxian Song; Yue Jing; Qingang Hu; Yanhong Ni

doi:10.3390/biom12030400

Identification of Metabolism-Associated Biomarkers for Early and Precise Diagnosis of Oral Squamous Cell Carcinoma

Biomolecules. 2022 Mar 4;12(3):400. doi: 10.3390/biom12030400.

Authors

Yuhan Wang¹, Xiaoxin Zhang¹, Shuai Wang¹, Zihui Li¹, Xinyang Hu¹, Xihu Yang², Yuxian Song¹, Yue Jing¹, Qingang Hu³, Yanhong Ni¹

Affiliations

¹ Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China.
² Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 210008, China.
³ Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China.

Abstract

The 5-year survival rate for oral squamous cell carcinoma (OSCC), one of the most common head and neck cancers, has not improved in the last 20 years. Poor prognosis of OSCC is the result of failure in early and precise diagnosis. Metabolic reprogramming, including the alteration of the uptake and utilisation of glucose, amino acids and lipids, is an important feature of OSCC and can be used to identify its biomarkers for early and precise diagnosis. In this review, we summarise how recent findings of rewired metabolic networks in OSCC have facilitated early and precise diagnosis of OSCC.

Keywords: biomarker; early diagnosis; metabolic reprogramming; oral squamous cell carcinoma; precise diagnosis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers, Tumor / metabolism
Carcinoma, Squamous Cell* / metabolism
Head and Neck Neoplasms*
Humans
Mouth Neoplasms* / metabolism
Squamous Cell Carcinoma of Head and Neck

Substances

Biomarkers, Tumor