Aberrant functional connectivity between anterior cingulate cortex and left insula in association with therapeutic response to biologics in inflammatory arthritis

Nobuya Abe; Yuichiro Fujieda; Khin K Tha; Hisashi Narita; Kuniyuki Aso; Kohei Karino; Masatoshi Kanda; Michihito Kono; Masaru Kato; Olga Amengual; Tatsuya Atsumi

doi:10.1016/j.semarthrit.2022.151994

Aberrant functional connectivity between anterior cingulate cortex and left insula in association with therapeutic response to biologics in inflammatory arthritis

Semin Arthritis Rheum. 2022 Aug:55:151994. doi: 10.1016/j.semarthrit.2022.151994. Epub 2022 Mar 15.

Authors

Affiliations

¹ Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8648, Japan.
² Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8648, Japan. Electronic address: edaichi@med.hokudai.ac.jp.
³ Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan; Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
⁴ Department of Psychiatry, Faculty of Medicine, Hokkaido University, Sapporo, Japan.
⁵ Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8648, Japan; Department of Rheumatology and Clinical Immunology, School of Medicine, Sapporo Medical University, Sapporo, Japan.

PMID: 35325802
DOI: 10.1016/j.semarthrit.2022.151994

Abstract

Background: Brain activity is reported to be associated with individual pain susceptibility and inflammatory status, possibly contributing to disease activity assessment in inflammatory arthritis (IA) including rheumatoid arthritis (RA) and spondyloarthritis (SpA). However, what alteration of brain function associated with disease activity and therapeutic effectiveness in IA remains unclear. We aimed to identify the alterations of brain functional connectivity (FC) shared in both RA and SpA, and evaluate its relationship to anti-rheumatic treatment response using functional magnetic resonance imaging (MRI).

Patients and methods: Structural and resting-state functional MRI data were acquired from patients with IA, patients with osteoarthritis (OA) and heathy controls (HCs). Two datasets were adopted to derive (51 IA, 56 OA, and 17 HCs) and validate (31 IA) the observations. 33 IA patients in the derivation dataset and all the patients in validation dataset required biological treatment and were clinically evaluated before and after therapy. Via whole-brain pair-wise FC analyses, we analyzed IA-specific FC measures relevant to therapeutic response to biologics.

Results: The value of FC between left insular cortex (IC) and anterior cingulate cortex (ACC) was significantly low in IA patients compared with OA patients and HCs. We demonstrated that the FC between left anterior long insular gyrus as a subdivision of IC and ACC was significantly associated with therapeutic response to biologics regarding the improvement of patients' global assessment (PGA) in both derivation and validation datasets.

Conclusion: Disease-specific resting-state FC provides a means to assess the therapeutic improvement of PGA and would be a clinical decision-making tool with predictability for treatment response in both RA and SpA.

Keywords: Functional connectivity; Neuroimaging; Patient reported outcome; Resting-state functional magnetic resonance imaging; Rheumatoid arthritis; Spondyloarthritis.

MeSH terms

Arthritis*
Biological Products*
Brain
Gyrus Cinguli / diagnostic imaging
Humans
Magnetic Resonance Imaging / methods

Substances

Biological Products