Amycolachromones A-F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1

Jianwei Chen; Jun Chen; Siqi Wang; Xiaoze Bao; Songwei Li; Bin Wei; Huawei Zhang; Hong Wang

doi:10.3390/md20030162

Amycolachromones A-F, Isolated from a Streptomycin-Resistant Strain of the Deep-Sea Marine Actinomycete Amycolatopsis sp. WP1

Mar Drugs. 2022 Feb 24;20(3):162. doi: 10.3390/md20030162.

Authors

Jianwei Chen¹, Jun Chen², Siqi Wang¹, Xiaoze Bao¹, Songwei Li¹, Bin Wei¹, Huawei Zhang¹, Hong Wang^{1

3}

Affiliations

¹ College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China.
² College of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu'an 237499, China.
³ Key Laboratory of Marine Fishery Resources Exploitment and Utilization of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, China.

Abstract

In this study, a detailed chemical investigation of a streptomycin-resistant strain of the deep-sea marine, actinomycete Amycolatopsis sp. WP1, yielded six novel amycolachromones A-F (1-6), together with five known analogues (7-11). Amycolachromones A-B (1-2) possessed unique dimer skeletons. The structures and relative configurations of compounds 1-11 were elucidated by extensive spectroscopic data analyses combined with X-ray crystal diffraction analysis. Plausible biogenetic pathways of amycolachromones A-F were also proposed.

Keywords: isolation; marine actinomycetes; secondary metabolites.

MeSH terms

Amycolatopsis / chemistry*
Amycolatopsis / metabolism
Anti-Bacterial Agents
Aquatic Organisms / chemistry
Chromones / chemistry
Chromones / isolation & purification*
Chromones / metabolism
Drug Resistance, Bacterial
Molecular Structure
Streptomycin

Substances

Anti-Bacterial Agents
Chromones
Streptomycin