Is It an Outbreak of Health Care-Associated Infection? An Investigation of Binocular Conjunctival Congestion After Laparoscopic Cholecystectomy Was Traced to Chitosan Derivatives

Sidi Liu; Xun Huang; Chenchao Fu; Qingya Dou; Jie Li; Xuelian Feng; Yang Mo; Xiujuan Meng; Cui Zeng; Anhua Wu; Chunhui Li

doi:10.3389/fmed.2022.759945

Is It an Outbreak of Health Care-Associated Infection? An Investigation of Binocular Conjunctival Congestion After Laparoscopic Cholecystectomy Was Traced to Chitosan Derivatives

Front Med (Lausanne). 2022 Mar 7:9:759945. doi: 10.3389/fmed.2022.759945. eCollection 2022.

Authors

Sidi Liu^{1

2}, Xun Huang^{1

2}, Chenchao Fu^{1

2}, Qingya Dou^{1

2}, Jie Li^{1

2}, Xuelian Feng^{2

3}, Yang Mo^{2

4}, Xiujuan Meng^{1

2}, Cui Zeng^{1

2}, Anhua Wu^{1

2}, Chunhui Li^{1

2}

Affiliations

¹ Infection Control Center, Xiangya Hospital of Central South University, Changsha, China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China.
³ Operating Room Department, Xiangya Hospital of Central South University, Changsha, China.
⁴ Day Ward Unit, Xiangya Hospital of Central South University, Changsha, China.

Abstract

Background: From May 6 to May 23, 2019, 24 (80.00%) patients who underwent laparoscopic cholecystectomy (LC) developed binocular conjunctival congestion within 4-8 h after their operation in the day ward of a teaching hospital.

Methods: Nosocomial infection prevention and control staff undertook procedural and environmental investigations, performed a case-control retrospective study (including 24 cases and 48 controls), and reviewed all lot numbers of biological material products to investigate the suspected outbreak of health care-associated infection.

Findings: Initially, an outbreak of health care-associated infection caused by bacteria was hypothesized. We first suspected the membranes that covered patients' eyes were cut using non-sterile scissors and thus contaminated, but they failed to yield bacteria. In addition, both corneal and conjunctival fluorescein staining results were negative in case-patients and isolated bacteria were ubiquitous in the environment or common skin commensals or normal flora of conjunctiva from 218 samples from day surgery and the day ward. Hence, we considered a non-infectious factor as the most likely cause of the binocular conjunctival congestion. Then, we found that case-patients were more likely than LC surgery patients without binocular conjunctival congestion to be exposed to biological materials in a retrospective case-control study. When we reviewed lot numbers, duration of use, and the number of patients who received four biological material products during LC in the day ward, we found that the BLK1821 lot of a modified chitosan medical membrance (the main ingredient is chitosan, a linear cationic polysaccharide) was used concurrently to when the case aggregation appeared. Finally, we surmised there was a correlation between this product and the outbreak of binocular conjunctival congestion. Relapse of the pseudo-outbreak has not been observed since stopping usage of the product for 6 months.

Conclusion: A cluster of binocular non-infectious conjunctival congestion diagnosed after LC proved to be a pseudo-outbreak. We should pay more attention to adverse events caused by biomaterials in hospitals.

Keywords: biological material; conjunctival congestion; health care-associated infection (HAI); nosocomial infection prevention and control; regulation.