Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion-Weighted MRI Metrics in Cognitive Decline

Abstract

Background: Advanced diffusion-based MRI biomarkers may provide insight into microstructural and perfusion changes associated with neurodegeneration and cognitive decline.

Purpose: To assess longitudinal microstructural and perfusion changes using apparent diffusion coefficient (ADC) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters in cognitively impaired (CI) and healthy control (HC) groups.

Study type: Prospective/longitudinal.

Population: Twelve CI patients (75% female) and 13 HC subjects (69% female).

Field strength/sequence: 3 T; Spin-Echo-IVIM-DWI.

Assessment: Two MRI scans were performed with a 12-month interval. ADC and IVIM-DWI metrics (diffusion coefficient [D] and perfusion fraction [f]) were generated from monoexponential and biexponential fits, respectively. Additionally, voxel-based correlations were evaluated between change in Montreal Cognitive Assessment (ΔMoCA) and baseline imaging parameters.

Statistical tests: Analysis of covariance with sex and age as covariates was performed for main effects of group and time (false discovery rate [FDR] corrected) with post hoc comparisons using Bonferroni correction. Partial-η² and Hedges' g were used for effect-size analysis. Spearman's correlations (FDR corrected) were used for the relationship between ΔMoCA score and imaging. P < 0.05 was considered statistically significant.

Results: Significant differences were found for the main effects of group (HC vs. CI) and time. For group effects, higher ADC, IVIM-D, and IVIM-f were observed in the CI group compared to HC (ADC: 1.23 ± 0.08^. 10^-3 vs. 1.09 ± 0.07^. 10^-3 mm² /sec; IVIM-D: 0.82 ± 0.01^. 10^-3 vs. 0.73 ± 0.01^. 10^-3 mm² /sec; and IVIM-f: 0.317 ± 0.008 vs. 0.253 ± 0.009). Significantly higher ADC, IVIM-D, and IVIM-f values were observed in the CI group after 12 months (ADC: 1.45 ± 0.05^. 10^-3 vs. 1.50 ± 0.07^. 10^-3 mm² /sec; IVIM-D: 0.87 ± 0.01^. 10^-3 vs. 0.94 ± 0.02^. 10^-3 mm² /sec; and IVIM-f: 0.303 ± 0.007 vs. 0.332 ± 0.008), but not in the HC group at large effect size. ADC, IVIM-D, and IVIM-f negatively correlated with ΔMoCA score (ρ = -0.49, -0.51, and -0.50, respectively).

Data conclusion: These findings demonstrate that longitudinal differences between CI and HC cohorts can be measured using IVIM-based metrics.

Level of evidence: 2 TECHNICAL EFFICACY STAGE: 2.

Keywords: Alzheimer's disease; apparent diffusion coefficient; diffusion MRI; intravoxel incoherent motion; mild cognitive impairment.