Expression of TMED3 is independently associated with colorectal cancer prognosis

Rong-Fei Wang; Yong-Gang Hong; Li-Qiang Hao; Hai-Tao Yu

doi:10.3892/etm.2022.11215

Expression of TMED3 is independently associated with colorectal cancer prognosis

Exp Ther Med. 2022 Apr;23(4):286. doi: 10.3892/etm.2022.11215. Epub 2022 Feb 15.

Authors

Rong-Fei Wang¹, Yong-Gang Hong², Li-Qiang Hao², Hai-Tao Yu³

Affiliations

¹ Department of Tumor, Anus and Intestine, Jinhua People's Hospital, Jinhua, Zhejiang 321000, P.R. China.
² Department of Colorectal Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, P.R. China.
³ Department of Oncology, Lanxi People's Hospital, Lanxi, Zhejiang 321100, P.R. China.

Abstract

Colorectal cancer (CRC) is the third most common cancer type and one of the deadliest cancers worldwide. Transmembrane p24 trafficking protein 3 (TMED3) has previously been indicated to suppress CRC metastasis, but its clinical significance has remained undetermined. In the present study, the expression of TMED3 was indicated to be elevated at the mRNA and protein levels in CRC tumor samples relative to that in para-cancerous healthy tissue samples (P<0.05). Furthermore, Kaplan-Meier survival analysis revealed a significant negative association between elevated TMED3 protein levels and overall survival of patients with CRC (P<0.001, log-rank test). Multivariate Cox regression analysis additionally determined that elevated TMED3 expression in primary CRC tumors was an independent predictor of poor prognosis (P<0.05). These results revealed that elevated TMED3 expression in CRC was associated with patient survival outcomes, suggesting that TMED3 may be a potential prognostic biomarker for this cancer type.

Keywords: biomarker; colorectal cancer; multivariate Cox regression analysis; prognosis; transmembrane p24 trafficking protein 3.

Grants and funding

Funding: This study was supported by a grant from the Natural Science Foundation of the Shanghai Science and Technology Commission (grant no. 16ZR1400800).