Metal organic framework loaded fluorescent nitrogen-doped carbon nanozyme with light regulating redox ability for detection of ferric ion and glutathione

Jun Zhao; Jiawen Gong; Jingnan Wei; Qi Yang; Guangjie Li; Yuping Tong; Weiwei He

doi:10.1016/j.jcis.2022.03.028

Metal organic framework loaded fluorescent nitrogen-doped carbon nanozyme with light regulating redox ability for detection of ferric ion and glutathione

J Colloid Interface Sci. 2022 Jul 15:618:11-21. doi: 10.1016/j.jcis.2022.03.028. Epub 2022 Mar 8.

Authors

Jun Zhao¹, Jiawen Gong¹, Jingnan Wei², Qi Yang³, Guangjie Li², Yuping Tong⁴, Weiwei He⁵

Affiliations

¹ Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Xuchang, Henan 461000, China; School of Civil Engineering and Communication, North China University of Water Resources and Electric Power, Zhengzhou, Henan 450045, China.
² Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Xuchang, Henan 461000, China.
³ Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Xuchang, Henan 461000, China. Electronic address: yangq@xcu.edu.cn.
⁴ School of Civil Engineering and Communication, North China University of Water Resources and Electric Power, Zhengzhou, Henan 450045, China. Electronic address: yptong_zz@163.com.
⁵ Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Xuchang, Henan 461000, China. Electronic address: heweiweixcu@gmail.com.

PMID: 35316708
DOI: 10.1016/j.jcis.2022.03.028

Abstract

The redox state disorder of biological system caused by oxidative stress can lead to a variety of clinical dysfunction and diseases. It is an important challenge to find artificial materials that can efficiently adjust the redox balance to maintain health. In this work, a nitrogen-doped carbon (NCDs) redox nanozyme loaded into metal organic framework (MOF, UiO-66) is designed to form NCDs/UiO-66 nanocomposites. The high specific surface area and porosity of UiO-66 serve as ideal carrier to support multifunctional NCDs. NCDs/UiO-66 nanocomposites are comprehensively investigated for their ability to scavenge or generate reactive oxygen species (ROS) and free radicals. Experimental results demonstrate that NCDs/UiO-66 can remove intrinsic free radicals (^•OH, O₂^•- and ABTS^•+), exhibiting superoxide dismutase-like activity and antioxidant capability. Moreover, NCDs/UiO-66 can efficiently produce ROS (^•OH, O₂^•- and ¹O₂) under irradiation showing light induced oxidase-like activity and pro-oxidant capability. This suggests the anti-oxidant and pro-oxidant activities of NCDs/UiO-66 could be regulated easily by light irradiation. Using the fluorescent property and light-activated oxidase-like activity of NCDs/UiO-66, the methods for detection of ferric ion (Fe³⁺) and glutathione (GSH) are developed.

Keywords: Antioxidant; Biological detection; Carbon dots; Light regulating; Nanozyme.

MeSH terms

Antioxidants
Carbon
Free Radicals
Glutathione
Iron
Metal-Organic Frameworks*
Nitrogen
Oxidation-Reduction
Oxidoreductases
Phthalic Acids
Reactive Oxygen Species

Substances

Antioxidants
Free Radicals
Metal-Organic Frameworks
Phthalic Acids
Reactive Oxygen Species
UiO-66
Carbon
Iron
Oxidoreductases
Glutathione
Nitrogen