A case of senile-onset progressive hemiballism and cognitive decline with diffuse brain iron accumulations

I-Ting Lin; Ni-Chung Lee; Sung-Pin Fan; Chang-Jin Huang; PoWei Cheng; Jyh-Horng Chen; Chin-Hsien Lin

doi:10.1016/j.parkreldis.2022.03.001

A case of senile-onset progressive hemiballism and cognitive decline with diffuse brain iron accumulations

Parkinsonism Relat Disord. 2022 May:98:114-117. doi: 10.1016/j.parkreldis.2022.03.001. Epub 2022 Mar 17.

Authors

I-Ting Lin¹, Ni-Chung Lee², Sung-Pin Fan¹, Chang-Jin Huang³, PoWei Cheng³, Jyh-Horng Chen³, Chin-Hsien Lin⁴

Affiliations

¹ Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
² Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan.
³ Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan.
⁴ Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: chlin@ntu.edu.tw.

PMID: 35314108
DOI: 10.1016/j.parkreldis.2022.03.001

Abstract

The etiologies for adults presenting with hemiballism are usually acquired lesions in the contralateral side of subthalamic nucleus. We present a 71-year-old woman with progressive onset of left hemiballism, orolingual dyskinesia and cognitive decline for 3 years. A rare genetic etiology was the final diagnosis for this index patient. In this movement disorder round, we describe our approach to this clinical presentation, and discuss the phenomenon and radiological features of this rare genetic disorder.

Keywords: Aceruloplasminemia; Ballism; Ceruloplasmin; Chorea; Iron; Neurodegeneration with brain iron accumulation.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cognitive Dysfunction* / complications
Dyskinesias* / complications
Dyskinesias* / etiology
Female
Humans
Iron
Movement Disorders* / etiology
Subthalamic Nucleus*

Substances

Iron