Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China

Mayina Kahaer; Bei Zhang; Wujin Chen; Meiting Liang; Yi He; Miao Chen; Rui Li; Tingting Tian; Cheng Hu; Yuping Sun

doi:10.3389/fendo.2022.861760

Triglyceride Glucose Index Is More Closely Related to Hyperuricemia Than Obesity Indices in the Medical Checkup Population in Xinjiang, China

Front Endocrinol (Lausanne). 2022 Mar 2:13:861760. doi: 10.3389/fendo.2022.861760. eCollection 2022.

Authors

Mayina Kahaer^{1

2}, Bei Zhang², Wujin Chen², Meiting Liang², Yi He², Miao Chen³, Rui Li², Tingting Tian², Cheng Hu^{4

5}, Yuping Sun²

Affiliations

¹ School of Public Health, Xinjiang Medical University, Urumqi, China.
² Department of Microbiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi, China.
³ Department of Rheumatology and Immunology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
⁴ Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
⁵ Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to the Southern Medical University, Shanghai, China.

Abstract

Background: Hyperuricemia (HUA) is a metabolic anomaly with an increased incidence rate, causing a global medical burden. Several studies have confirmed that obesity and insulin resistance (IR) are the risk factors for HUA. Reports on the predictive power of different obesity indices for HUA are limited. This study aimed to compare the association between different general, abdominal, and visceral obesity indices and markers of the IR-triglyceride glucose (TyG) index with serum uric acid (SUA) and to assess the ability of these indices to predict HUA.

Methods: A total of 2243 participants were recruited from Barkol County Hospital and surrounding township hospitals in Xinjiang. Obesity indices, including the atherogenic index of plasma, cardiometabolic index, visceral adiposity index, lipid accumulation product index, a body shape index, body roundness index, waist circumference, waist-to-height ratio, body mass index, and TyG index, were divided into four quartiles. Moreover, partial correlations and logistic regression were used to analyze the association between these indices and SUA. The area under the curve (AUC) and receiver operating characteristic curves were used to analyze the predictive value of these indices for HUA.

Results: After controlling for confounding variables, the association between the TyG index and HUA was stronger than that between the obesity indices in both males and females. The odds ratios (ORs) for HUA in the highest quartile of the TyG index were 2.098 (95% confidence interval, 1.555-2.831) in males and 7.788 (95% CI, 3.581-16.937) in females. For males, the AIP, CMI, VAI, LAP index, and TyG index were able to discriminate HUA, and the TyG index showed the highest AUC value of 0.586 (95% CI, 0.557-0.614; P < 0.001). For females, all indices, except BMI, can discriminate HUA. Moreover, the visceral obesity index CMI showed the highest AUC value of 0.737 (95% CI, 0.691-0.782; P < 0.001). Meanwhile, the TyG index had a relatively high AUC value of 0.728 (95% CI, 0.682-0.773; P < 0.001).

Conclusion: The TyG index was significantly related to HUA and was superior to obesity indices in identifying HUA in the medical checkup population in Xinjiang, China.

Keywords: Triglyceride glucose index; hyperuricemia; medical checkup population; obesity indices; serum uric acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

China / epidemiology
Female
Glucose
Humans
Hyperuricemia* / diagnosis
Hyperuricemia* / epidemiology
Insulin Resistance*
Male
Obesity / epidemiology
Obesity, Abdominal / diagnosis
Obesity, Abdominal / epidemiology
Triglycerides
Uric Acid

Substances

Triglycerides
Uric Acid
Glucose