Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis

Hua Huang; Zijian Shi; Yongwen Li; Guangsheng Zhu; Chen Chen; Zihe Zhang; Ruifeng Shi; Lianchun Su; Peijun Cao; Zhenhua Pan; Hongbing Zhang; Minghui Liu; Hongyu Liu; Jun Chen

doi:10.3389/fonc.2022.850943

Pyroptosis-Related LncRNA Signatures Correlate With Lung Adenocarcinoma Prognosis

Front Oncol. 2022 Mar 2:12:850943. doi: 10.3389/fonc.2022.850943. eCollection 2022.

Authors

Hua Huang¹, Zijian Shi¹, Yongwen Li², Guangsheng Zhu¹, Chen Chen², Zihe Zhang¹, Ruifeng Shi¹, Lianchun Su³, Peijun Cao¹, Zhenhua Pan², Hongbing Zhang¹, Minghui Liu¹, Hongyu Liu^{2

4}, Jun Chen^{1

2

3}

Affiliations

¹ Department of Lung Cancer Surgery, Tianjin Medical University General Hospital, Tianjin, China.
² Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
³ Department of Thoracic Surgery, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China.
⁴ Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Abstract

Background: Pyroptosis is a new type of programmed cell death, accompanied by an intense inflammatory response. Previous studies have shown that pyroptosis can modify long-chain non-coding RNA (lncRNA), thereby affecting the occurrence and progression of tumors. However, the underlying role of pyroptosis-related lncRNA in lung adenocarcinoma (LUAD) remains to be elucidated. Therefore, the purpose of our study was to evaluate the prognostic value of pyrolysis-related lncRNA in patients with LUAD.

Methods: A total of 454 LUAD samples were downloaded from The Cancer Genome Atlas (TCGA) database. Pearson's correlation coefficient was used to identify the pyroptosis-related lncRNAs. Unsupervised consensus clustering was used to identify the various LUAD molecular subtypes. A least absolute shrinkage and selection operator (LASSO) analysis was conducted to construct a prognostic signature.

Results: An 11-lncRNA prognostic signature out of 19 identified pyroptosis-related prognostic lncRNAs was constructed. The patients with LUAD were divided into low-risk and high-risk groups. Patients in the high-risk group had higher score values and mortality. The immune score, stromal score, and estimate score were lower in the high-risk group. The risk score was an independent predictor for OS in multivariate Cox regression analyses (HR > 1, p < 0.01). BTLA, PD-1, PD-L1, CTLA, and CD47 were lower expressed in the high-risk group.

Conclusions: Our study identified an 11-pyroptosis-related lncRNA signature. These findings could further clarify the role of pyroptosis in LUAD and guide the prognosis and individualized treatment of patients.

Keywords: immune cell infiltrating; immune checkpoint; lncRNA; prognosis; pyroptosis.