A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition

Xianwen Zou; Guiqi Ma; Pengyu Zhu; Yutao Cao; Xiao Sun; Haijun Wang; Jian Dong

doi:10.3389/fonc.2022.860718

A Polydopamine-Coated Platinum Nanoplatform for Tumor-Targeted Photothermal Ablation and Migration Inhibition

Front Oncol. 2022 Mar 3:12:860718. doi: 10.3389/fonc.2022.860718. eCollection 2022.

Authors

Xianwen Zou¹, Guiqi Ma¹, Pengyu Zhu¹, Yutao Cao¹, Xiao Sun¹, Haijun Wang², Jian Dong¹

Affiliations

¹ Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
² School of Life Sciences, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.

Abstract

In this work, Arg-Gly-Asp (RGD) peptide-coupled polydopamine-modified mesoporous platinum nanoparticles (mPt@PDA-RGD NPs) were developed for targeted photothermal therapy (PTT) and migration inhibition of SKOV-3 cells. mPt@PDA-RGD NPs with obvious core/shell structure demonstrated high photothermal performance under 808-nm near-infrared (NIR) laser irradiation. mPt@PDA-RGD NPs with favorable biocompatibility exhibited remarkable SKOV-3 inhibition ability under NIR laser irradiation. Moreover, compared to mPt@PDA NPs, the RGD-functionalized NPs achieved more tumor uptake and PTT performance, which was attributed to the specific interaction between RGD of NPs and α_vβ₃ integrin overexpressed by SKOV-3. Importantly, cell scratch experiments indicated that the photothermal effect of mPt@PDA-RGD NPs can effectively inhibit the migration of surviving SKOV-3 cells, which was assigned to disturbance of the actin cytoskeleton of SKOV-3. Thus, mPt@PDA-RGD NPs presented great potential for targeted tumor photothermal ablation and migration inhibition.

Keywords: PTT; RGD target; migration inhibition; photothermal ablation; platinum nanoplatform.