Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction

Tianyu Shen; Dayin Lyu; Mengping Zhang; Hui Shang; Qiulun Lu

doi:10.3389/fcvm.2022.783426

Dioscin Alleviates Cardiac Dysfunction in Acute Myocardial Infarction via Rescuing Mitochondrial Malfunction

Front Cardiovasc Med. 2022 Mar 4:9:783426. doi: 10.3389/fcvm.2022.783426. eCollection 2022.

Authors

Tianyu Shen¹, Dayin Lyu², Mengping Zhang³, Hui Shang¹, Qiulun Lu²

Affiliations

¹ Department of Orthopaedic, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
² Key Laboratory of Cardiovascular and Cerebrovascular Medicine, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University, Nanjing, China.
³ Department of Hematology, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Abstract

Myocardial infarction is one of the most severe heart diseases, leading to sudden death. Currently, angiography and stenting are widely performed in clinics, yet more effective treatment is still needed. Herein, we presented that dioscin, a natural product, showed protective effect on infarcted hearts via mitochondrial maintenance. Upon dioscin treatment, cardiac dysfunction was alleviated, and remodeling is prevented. Mechanistically, disocin maintains mitochondria function through the maintenance of Kreb's cycle, and suppresion of ROS accumulation. In this way, by targeting mitochondrial dysfunction, dioscin is a potential drug for infarcted hearts.

Keywords: KREB'S cycle; ROS; dioscin; mitochondrial dysfunction; myocardial infarction.