Functional magnetic resonance imaging data for the association between polygenic risk scores for neuroticism and reward-punishment processing

Heekyeong Park; Katherine L Forthman; Rayus Kuplicki; Teresa A Victor; Tulsa 1000 Investigators; Hung-Wen Yeh; Wesley K Thompson; Martin P Paulus

doi:10.1016/j.dib.2022.108014

Functional magnetic resonance imaging data for the association between polygenic risk scores for neuroticism and reward-punishment processing

Data Brief. 2022 Mar 4:42:108014. doi: 10.1016/j.dib.2022.108014. eCollection 2022 Jun.

Authors

Heekyeong Park^{1

2}, Katherine L Forthman¹, Rayus Kuplicki¹, Teresa A Victor¹; Tulsa 1000 Investigators; Hung-Wen Yeh^{1

3}, Wesley K Thompson⁴, Martin P Paulus¹

Affiliations

¹ Laureate Institute for Brain Research, Tulsa, OK, USA.
² University of North Texas at Dallas, Dallas, TX, USA.
³ Children's Mercy Hospital, Kansas City, MO, USA.
⁴ University of California, San Diego, CA, USA.

Abstract

Neuroticism as a personality trait represents a heritable risk for psychiatric disorders. The polygenic risk score for neuroticism (N-PRS) is used to study genetic vulnerability to neuroticism. The current data present the association of the genetic risk for neuroticism to neural reward-punishment processing using functional magnetic resonance imaging. N-PRS was computed based on the individual's genotype information and a genome-wide association study on the UK Biobank data. While individuals performed a monetary incentive delay task, their neural activations for upcoming incentives (reward: gain, punishment: loss) were measured in blood oxygen level dependent (BOLD) signals during the delay phase. Multivariate ANCOVAs were used to analyze BOLD signals for finding the association between N-PRS and reward-punishment processing by the incentive valence (Related research article: H. Park, K.L. Forthman, R. Kuplicki, T.A. Victor, Tulsa 1000 Investigators, H.W. Yeh, W.K. Thompson, M.P. Paulus, Polygenic risk for neuroticism modulates response to gains and losses in the amygdala and caudate: evidence from a clinical cohort. J. Affect. Disord. 293 (2021) 124-132. https://doi.org/10.1016/j.jad.2021.06.016). These data can be used as reference data for future studies examining the role of the genetic propensity for personality traits in the context of psychiatric disorders.

Keywords: Genetics; Neuroticism; Polygenic risk score; Reward; fMRI.

Abstract

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