Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

Tongxia Jin; Di Cheng; Guanyu Jiang; Wenqian Xing; Peiwen Liu; Bin Wang; Weiping Zhu; Haitao Sun; Zhenrong Sun; Yufang Xu; Xuhong Qian

doi:10.1016/j.bioactmat.2021.12.009

Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT/PTT/chemotherapy

Bioact Mater. 2021 Dec 20:14:42-51. doi: 10.1016/j.bioactmat.2021.12.009. eCollection 2022 Aug.

Authors

Tongxia Jin^{1

2}, Di Cheng¹, Guanyu Jiang³, Wenqian Xing^{1

2}, Peiwen Liu^{1

2}, Bin Wang¹, Weiping Zhu^{1

2}, Haitao Sun³, Zhenrong Sun³, Yufang Xu¹, Xuhong Qian^{1

2}

Affiliations

¹ State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China.
² Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
³ State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, PR China.

Abstract

Photodynamic (PDT) and photothermal therapies (PTT) are emerging treatments for tumour ablation. Organic dyes such as porphyrin, chlorin, phthalocyanine, boron-dipyrromethene and cyanine are the clinically or preclinically used photosensitizer or photothermal agents. Development of structurally diverse near-infrared dyes with long absorption wavelength is of great significance for PDT and PTT. Herein, we report a novel near-infrared dye ML880 with naphthalimide modified cyanine skeleton. The introduction of naphthalimide moiety results in stronger electron delocalization and larger redshift in emission compared with IR820. Furthermore, ML880 is co-loaded with chemotherapeutic drug into ROS-responsive mesoporous organosilica (RMON) to construct nanomedicine NBD&ML@RMON, which exhibits remarkable tumor inhibition effects through PDT/PTT/chemotherapy in vivo.

Keywords: Combination therapy; Drug delivery system; Integration strategy; Near-infrared dye; Phototherapy.