Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis

Suwen Bai; Zunyun Wang; Minghua Wang; Junai Li; Yuan Wei; Ruihuan Xu; Juan Du

doi:10.3389/fcell.2022.752818

Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis

Front Cell Dev Biol. 2022 Mar 2:10:752818. doi: 10.3389/fcell.2022.752818. eCollection 2022.

Authors

Suwen Bai^{1

2}, Zunyun Wang², Minghua Wang¹, Junai Li¹, Yuan Wei¹, Ruihuan Xu¹, Juan Du¹

Affiliations

¹ Longgang District People´s Hospital of Shenzhen, The Second Affiliated Hospital of The Chinese University of Hong Kong, Shenzhen, China.
² School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Abstract

Tumor-derived exosomes (TDEs) are actively produced and released by tumor cells and carry messages from tumor cells to healthy cells or abnormal cells, and they participate in tumor metastasis. In this review, we explore the underlying mechanism of action of TDEs in tumor metastasis. TDEs transport tumor-derived proteins and non-coding RNA to tumor cells and promote migration. Transport to normal cells, such as vascular endothelial cells and immune cells, promotes angiogenesis, inhibits immune cell activation, and improves chances of tumor implantation. Thus, TDEs contribute to tumor metastasis. We summarize the function of TDEs and their components in tumor metastasis and illuminate shortcomings for advancing research on TDEs in tumor metastasis.

Keywords: angiogenesis; immunosuppression; metastasis; pre-metastatic niche; tumor-derived exosomes.

Publication types

Review