Understanding the Effects of Age and T-Cell Differentiation on COVID-19 Severity: Implicating a Fas/FasL-mediated Feed-Forward Controller of T-Cell Differentiation

Front Immunol. 2022 Mar 3:13:853606. doi: 10.3389/fimmu.2022.853606. eCollection 2022.

Authors

Anthony J Leonardi¹, Christos P Argyropoulos², Adam Hamdy³, Rui B Proenca⁴

Affiliations

¹ Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
² Department of Internal Medicine, Division of Nephrology, University of New Mexico School of Medicine, Albuquerque, NM, United States.
³ Independent Researcher, Port Louis, Mauritius.
⁴ Department of Biology, Johns Hopkins University, Baltimore, MD, United States.

No abstract available

Keywords: CD8; Fas; FasL; SARS-CoV-2; T cells; differentiation; feed-forward Loop; paracrine.

MeSH terms

Age Factors
Aging / physiology*
COVID-19 / immunology*
Cell Differentiation
Fas Ligand Protein / metabolism
Feedback, Physiological
Humans
Models, Biological
SARS-CoV-2 / physiology*
Severity of Illness Index
T-Lymphocytes / immunology*
fas Receptor / metabolism

Substances

Fas Ligand Protein
fas Receptor