Comparative Assessment of the Effects of Hydroxyethyl Starch and Normal Saline on Severe Hypotension in Patients with Aluminum Phosphide Poisoning: A Retrospective Study

Amin Nakhostin-Ansari; Gholamabbas Kafi; Mohammad Arefi; Nasrin Barzegari Dahaj; Samaneh Akbarpour; Asieh Mansouri; Behnam Behnoush; Davood Soroosh

doi:10.1155/2022/4985120

Comparative Assessment of the Effects of Hydroxyethyl Starch and Normal Saline on Severe Hypotension in Patients with Aluminum Phosphide Poisoning: A Retrospective Study

J Toxicol. 2022 Mar 9:2022:4985120. doi: 10.1155/2022/4985120. eCollection 2022.

Authors

Amin Nakhostin-Ansari¹, Gholamabbas Kafi², Mohammad Arefi³, Nasrin Barzegari Dahaj⁴, Samaneh Akbarpour^{5

6}, Asieh Mansouri⁷, Behnam Behnoush², Davood Soroosh⁸

Affiliations

¹ Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
² Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Tehran, Iran.
³ Baharloo Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
⁴ Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.
⁷ Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
⁸ Department of Forensic Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran.

Abstract

Background: Aluminum phosphide poisoning is one of the most common forms of poisoning which requires immediate and urgent treatment.

Objective: This study aimed to compare the efficiency of two solutions, including hydroxyethyl starch and normal saline, in treating hypotension in patients with aluminum phosphide poisoning.

Methods: This retrospective cohort study was conducted on 35 patients with aluminum phosphide poisoning. We reviewed the profile of 18 patients treated with hydroxyethyl starch and 17 patients treated with normal saline. Within-group and between-group differences in systolic blood pressure before and after treatment were compared using paired t-test and independent t-test, respectively.

Results: The mean ± standard deviation (SD) age of the subjects in the starch and normal saline groups was 27.06 ± 9.72 and 27.88 ± 9.08, respectively. The levels of blood pressure in the two groups were not significantly different before the treatment; the mean ± SD of systolic blood pressure in the starch and normal saline groups was 72.67 ± 14.49 and 68.59 ± 8.3, respectively (P=0.313). After the treatment, it was significantly increased to 94 ± 24.45 and 85.18 ± 19.9 in the starch group (P=0.001) and the normal saline group (P=0.004), respectively. However, there was no significant difference between the two groups (P=0.245). Only one person survived in each group.

Conclusion: According to the results of this study, although there was no significant difference between the two groups in terms of their effects on hypotension, these treatments could not prevent mortality.