Rapidly progressive crescentic diabetic nephropathy: two case reports

Jade E Schroers; Alexander M Gilbert; Paul R McKenzie; Paul D Kirwan; Steven J Chadban; Tracey Ying

doi:10.1111/imj.15702

Rapidly progressive crescentic diabetic nephropathy: two case reports

Intern Med J. 2022 Mar;52(3):479-484. doi: 10.1111/imj.15702.

Authors

Jade E Schroers¹, Alexander M Gilbert¹, Paul R McKenzie², Paul D Kirwan³, Steven J Chadban⁴, Tracey Ying⁴

Affiliations

¹ Kidney Centre, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
² Department of Tissue Pathology and Diagnostic Oncology, NSWHP, Royal Prince Alfred Hospital, University of Sydney, Sydney, New South Wales, Australia.
³ NSWHP Electron Microscopy Unit, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
⁴ Kidney Centre, Royal Prince Alfred Hospital, Kidney Node Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.

PMID: 35307932
DOI: 10.1111/imj.15702

Abstract

Crescents are not a well recognised feature of diabetic nephropathy. We present two cases of patients presenting with a rapid decline in renal function and subacute onset of nephrotic syndrome. Glomerulonephritis screening was negative, and renal biopsy revealed non-necrotising cellular crescents and typical features of late-stage diabetic nephropathy. We review the literature for diabetic nephropathy with crescents and explore possible underlying mechanisms.

Keywords: biopsy; chronic kidney disease; crescent; diabetic nephropathy; nephrotic syndrome.

Publication types

Case Reports
Review

MeSH terms

Biopsy / adverse effects
Diabetes Mellitus*
Diabetic Nephropathies* / complications
Diabetic Nephropathies* / diagnosis
Female
Glomerulonephritis* / complications
Glomerulonephritis* / diagnosis
Humans
Male
Nephrotic Syndrome*