Immunoengineering strategies to enhance vascularization and tissue regeneration

Jana Zarubova; Mohammad M Hasani-Sadrabadi; Reza Ardehali; Song Li

doi:10.1016/j.addr.2022.114233

Immunoengineering strategies to enhance vascularization and tissue regeneration

Adv Drug Deliv Rev. 2022 May:184:114233. doi: 10.1016/j.addr.2022.114233. Epub 2022 Mar 15.

Authors

Jana Zarubova¹, Mohammad M Hasani-Sadrabadi², Reza Ardehali³, Song Li⁴

Affiliations

¹ Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Department of Biomaterials and Tissue Engineering, Institute of Physiology of the Czech Academy of Sciences, Prague 14220, Czech Republic.
² Department of Bioengineering, University of California, Los Angeles, CA 90095, USA.
³ Division of Cardiology, Department of Internal Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁴ Department of Bioengineering, University of California, Los Angeles, CA 90095, USA; Eli and Edythe Broad Stem Cell Research Center, University of California, Los Angeles, CA 90095, USA; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: songli@ucla.edu.

Abstract

Immune cells have emerged as powerful regulators of regenerative as well as pathological processes. The vast majority of regenerative immunoengineering efforts have focused on macrophages; however, growing evidence suggests that other cells of both the innate and adaptive immune system are as important for successful revascularization and tissue repair. Moreover, spatiotemporal regulation of immune cells and their signaling have a significant impact on the regeneration speed and the extent of functional recovery. In this review, we summarize the contribution of different types of immune cells to the healing process and discuss ways to manipulate and control immune cells in favor of vascularization and tissue regeneration. In addition to cell delivery and cell-free therapies using extracellular vesicles, we discuss in situ strategies and engineering approaches to attract specific types of immune cells and modulate their phenotypes. This field is making advances to uncover the extraordinary potential of immune cells and their secretome in the regulation of vascularization and tissue remodeling. Understanding the principles of immunoregulation will help us design advanced immunoengineering platforms to harness their power for tissue regeneration.

Keywords: Biomaterial; Cell delivery; Extracellular vesicles; Immune cell metabolism; Immunomodulation; Macrophages; Neutrophils; Patterning; Stiffness; T cells.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Biocompatible Materials
Humans
Immunity
Macrophages*
Wound Healing*

Substances

Biocompatible Materials

Abstract

Publication types

MeSH terms

Substances

Grants and funding