Chaperoning heterochromatin: new roles of FACT in chromatin silencing

Magdalena Murawska; Sigurd Braun

doi:10.1016/j.tig.2022.02.011

Chaperoning heterochromatin: new roles of FACT in chromatin silencing

Trends Genet. 2022 Jul;38(7):646-649. doi: 10.1016/j.tig.2022.02.011. Epub 2022 Mar 16.

Authors

Magdalena Murawska¹, Sigurd Braun²

Affiliations

¹ Physiological Chemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany. Electronic address: magdalena.murawska@bmc.med.lmu.de.
² Physiological Chemistry, Biomedical Center, Faculty of Medicine, Ludwig-Maximilians-University Munich, 82152 Planegg-Martinsried, Germany; Institute for Genetics, Justus-Liebig University Giessen, 35392 Giessen, Germany.

PMID: 35303999
DOI: 10.1016/j.tig.2022.02.011

Abstract

The multitasking histone chaperone FACT (FAcilitates Chromatin Transcription) contributes to actively transcribed euchromatin and repressed heterochromatin. However, its precise role in gene silencing has remained obscure. Here, we discuss new insights into the silent chromatin functions and recruitment mechanisms of FACT, and their possible implications in cell identity and cancer.

Keywords: FACT; H3K9 methylation; heterochromatin spreading; histone turnover.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatin / genetics
Euchromatin
Gene Silencing
Heterochromatin* / genetics
Histones* / genetics
Histones* / metabolism

Substances

Chromatin
Euchromatin
Heterochromatin
Histones