Effect of intrahepatic cholestasis of pregnancy on infantile food allergy: A retrospective longitudinal study cohort in Southwest China

Liqiong Huang; Xin Li; Tianjiao Liu; Lu Wei; Conghong Fan; Dongmei Tang; Wen Xiong; Yalan Li; Sumei Wei; Zhengai Xiong

doi:10.1016/j.ejogrb.2022.03.026

Effect of intrahepatic cholestasis of pregnancy on infantile food allergy: A retrospective longitudinal study cohort in Southwest China

Eur J Obstet Gynecol Reprod Biol. 2022 May:272:110-115. doi: 10.1016/j.ejogrb.2022.03.026. Epub 2022 Mar 14.

Authors

Liqiong Huang¹, Xin Li², Tianjiao Liu², Lu Wei², Conghong Fan², Dongmei Tang², Wen Xiong², Yalan Li³, Sumei Wei⁴, Zhengai Xiong⁵

Affiliations

¹ The Second Affiliated Hospital of Chongqing Medical University, Chongqing 610000, China; Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.
² Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China.
³ The Fourth People's Hospital of Chengdu, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: 1370343325@qq.com.
⁴ Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China. Electronic address: weisumeicwcch@aliyun.com.
⁵ The Second Affiliated Hospital of Chongqing Medical University, Chongqing 610000, China. Electronic address: 300534@hospital.cqmu.edu.cn.

PMID: 35303672
DOI: 10.1016/j.ejogrb.2022.03.026

Abstract

Introduction: Intrahepatic cholestasis of pregnancy has been consistently associated with a higher incidence of adverse pregnancy outcomes. Previous studies mainly focused on the effects of intrahepatic cholestasis of pregnancy on pregnant mothers and fetuses, and few studies reported the postpartum growth and development of fetuses in pregnant women with intrahepatic cholestasis of pregnancy. The aim of this study was to investigate impact of maternal serum total bile acid levels on maternal and neonatal outcomes as well as child growth and food allergy.

Material and methods: A retrospective longitudinal cohort investigation was carried out among 751 pregnant women with intrahepatic cholestasis of pregnancy at 30-32 weeks of gestation from the Longitudinal Intrahepatic Cholestasis of Pregnancy Study (LoICPS). Data on the characteristics of the mothers and neonates were collected. Infant growth data and food sensitivities were also collected.

Results: In our cohort, the average maternal serum total bile acid level was 35.09±30.02 μmol/L, with 58.8% of mothers suffering from mild intrahepatic cholestasis of pregnancy and 29.2% suffering from severe intrahepatic cholestasis of pregnancy. Positive correlations were found between maternal serum total bile acid levels and twin pregnancy (beta-value: 11.55, 95% CI: 2.89 - 20.20. P = 0.009) and meconium stained amniotic fluid (beta-value: 14.64, 95% CI: 9.41 - 19.87. P < 0.001). In addition, the infants of mothers with severe intrahepatic cholestasis of pregnancy were more likely to be allergic to foods at 6 months.

Conclusions: This study suggested that despite pregnant women with intrahepatic cholestasis of pregnancy taking ursodeoxycholic acid tablets and cesarean section before expected date of childbirth, the perinatal outcome of newborns partially improving, the incidence of infantile food allergy was still increased.

Keywords: Food allergy; Intrahepatic cholestasis of pregnancy; Pregnant women; Retrospective study.

MeSH terms

Bile Acids and Salts
Cesarean Section
Child
Cholestasis, Intrahepatic* / complications
Cholestasis, Intrahepatic* / epidemiology
Female
Food Hypersensitivity* / complications
Food Hypersensitivity* / epidemiology
Humans
Infant, Newborn
Longitudinal Studies
Pregnancy
Pregnancy Complications* / drug therapy
Pregnancy Complications* / epidemiology
Pregnancy Outcome / epidemiology
Retrospective Studies

Substances

Bile Acids and Salts

Supplementary concepts

Intrahepatic Cholestasis of Pregnancy