In unity, there is strength: Phase separation controls receptor tyrosine kinase signal transduction

Andres Jimenez Salinas; Young Kwang Lee

doi:10.1016/j.molcel.2022.03.003

In unity, there is strength: Phase separation controls receptor tyrosine kinase signal transduction

Mol Cell. 2022 Mar 17;82(6):1081-1083. doi: 10.1016/j.molcel.2022.03.003.

Authors

Andres Jimenez Salinas¹, Young Kwang Lee²

Affiliations

¹ Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA.
² Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA 92182, USA. Electronic address: youngkwang.lee@sdsu.edu.

PMID: 35303480
DOI: 10.1016/j.molcel.2022.03.003

Abstract

Lin et al. (2022) discover that FGFR2 undergoes liquid-liquid phase separation with its downstream effectors SHP2 and PLCγ1, and the formation of phase separated condensates is essential for signaling competency.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Protein Tyrosine Phosphatase, Non-Receptor Type 11* / metabolism
Protein-Tyrosine Kinases* / metabolism
Signal Transduction

Substances

Protein-Tyrosine Kinases
Protein Tyrosine Phosphatase, Non-Receptor Type 11