Sesquiterpene lactones from Artemisia mongolica

Ziwei Zhu; Ablajan Turak; Haji Akber Aisa

doi:10.1016/j.phytochem.2022.113158

Sesquiterpene lactones from Artemisia mongolica

Phytochemistry. 2022 Jul:199:113158. doi: 10.1016/j.phytochem.2022.113158. Epub 2022 Mar 14.

Authors

Ziwei Zhu¹, Ablajan Turak², Haji Akber Aisa³

Affiliations

¹ The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; University of the Chinese Academy of Sciences, Beijing, 100039, China.
² The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
³ The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China; State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China. Electronic address: haji@ms.xjb.ac.cn.

PMID: 35301035
DOI: 10.1016/j.phytochem.2022.113158

Abstract

Twelve undescribed sesquiterpene lactones and seven known sesquiterpene lactones were isolated from the whole plant of Artemisia mongolica. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data. The absolute configurations of mongolicolide A (1), mongolicolide C (3), 1R, 3S-Dihydroxy-7S, 11R-germacra-4Z.9Z-dien-12, 6S-olide (5), indicumolide E (9), indicumolide F (10), and indicumolide G (11) were determined by single-crystal X-ray crystallography. The X-ray crystal structure of artabsinolide E (15) was reported for the first time. In addition, beibersteneolide-B (13) showed moderate anti-inflammatory activity and marked antitumor activity, artemyriantholide E (18) show moderate antitumor activity.

Keywords: Anti-inflammatory; Antitumor; Artemisia mongolica; Asteraceae; Sesquiterpene lactones; Single-crystal X-ray analysis.

MeSH terms

Artemisia* / chemistry
Asteraceae* / chemistry
Lactones / chemistry
Lactones / pharmacology
Molecular Structure
Phytochemicals
Sesquiterpenes* / chemistry
Sesquiterpenes* / pharmacology

Substances

Lactones
Phytochemicals
Sesquiterpenes