Effects of galantamine on social interaction impairments in cholecystokinin receptor-2 overexpression mice

Shota Tanase; Takayoshi Mamiya; Shogo Nagata; Yusuke Ikawa; Ya-Ping Tang; Masayuki Hiramatsu; Toshitaka Nabeshima

doi:10.1016/j.jphs.2022.02.006

Effects of galantamine on social interaction impairments in cholecystokinin receptor-2 overexpression mice

J Pharmacol Sci. 2022 Apr;148(4):364-368. doi: 10.1016/j.jphs.2022.02.006. Epub 2022 Feb 21.

Authors

Shota Tanase¹, Takayoshi Mamiya², Shogo Nagata¹, Yusuke Ikawa¹, Ya-Ping Tang³, Masayuki Hiramatsu⁴, Toshitaka Nabeshima⁵

Affiliations

¹ Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
² Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan. Electronic address: mamiya@meijo-u.ac.jp.
³ Joint Center of Translational Precision Medicine, Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China.
⁴ Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan.
⁵ Japanese Drug Organization of Appropriate Use and Research, Nagoya, Japan; Advanced Diagnostic System Research Laboratory, Graduate School of Health Sciences, Fujita Health University, Toyoake, Japan.

PMID: 35300811
DOI: 10.1016/j.jphs.2022.02.006

Abstract

We examined whether galantamine (GAL), a cholinesterase inhibitor and allosteric potentiating ligand for α7 nicotinic acetylcholine receptor (nAChR), had an impact on emotional abnormalities in forebrain-specific cholecystokinin receptor-2 overexpressed transgenic mice. Treatment with GAL (1 mg/kg, s.c.) attenuated the decrease of social interaction time, but failed to attenuate anxiety-like behavior in the elevated plus-maze test. The effect of GAL was blocked by an α7 nAChR antagonist, methyllycaconitine (3 mg/kg, i.p.). These results suggest that GAL improved social interaction impairments via α7 nAChR and could be useful to treat sociability-related emotional abnormalities.

Keywords: Cholecystokinin receptor transgenic mice; Galantamine; Social interaction.

MeSH terms

Animals
Cholinesterase Inhibitors* / pharmacology
Cholinesterase Inhibitors* / therapeutic use
Galantamine* / pharmacology
Galantamine* / therapeutic use
Mice
Receptor, Cholecystokinin B* / genetics
Receptor, Cholecystokinin B* / metabolism
Social Behavior Disorders* / drug therapy
Social Interaction* / drug effects
alpha7 Nicotinic Acetylcholine Receptor / antagonists & inhibitors*

Substances

Cholinesterase Inhibitors
Receptor, Cholecystokinin B
alpha7 Nicotinic Acetylcholine Receptor
Galantamine