[Research Progress of Fatty Acid Desaturase 2 Gene in Glycolipid Metabolism]

Guo-Jie Wang; Ye Tian; Hui-Ying Zhang

doi:10.3881/j.issn.1000-503X.14235

[Research Progress of Fatty Acid Desaturase 2 Gene in Glycolipid Metabolism]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Feb;44(1):158-163. doi: 10.3881/j.issn.1000-503X.14235.

[Article in Chinese]

Authors

Guo-Jie Wang¹, Ye Tian¹, Hui-Ying Zhang¹

Affiliation

¹ Department of Obstetrics and Gynecology,Tianjin Medical University General Hospital,Tianjin 300052,China.

PMID: 35300779
DOI: 10.3881/j.issn.1000-503X.14235

Abstract

The fatty acid desaturase 2 (FADS2) gene encodes delta-6 desaturase (D6D) and is a member of the fatty acid desaturase gene family.D6D is the key enzyme catalyzing the transformation of linoleic acid and α-linolenic acid to long-chain polyunsaturated fatty acid (LC-PUFA).LC-PUFA play a crucial role in regulating the glycolipid metabolism of living organisms.In recent years,the activity of D6D and the single nucleotide polymorphism (SNP) of FADS2 gene have become a hot topic in the research on glycolipid metabolism.This article reviews the role of FADS2 gene in glycolipid metabolism.

Keywords: delta-6 desaturase; fatty acid desaturase 2 gene; glucose metabolism; lipid metabolism.

Publication types

Review

MeSH terms

Fatty Acid Desaturases* / genetics
Fatty Acid Desaturases* / metabolism
Glycolipids* / metabolism
Humans
Polymorphism, Single Nucleotide

Substances

Glycolipids
Fatty Acid Desaturases
FADS2 protein, human