Coinfection by Aspergillus and Mucoraceae Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19

Payam Tabarsi; Somayeh Sharifynia; Mihan Pourabdollah Toutkaboni; Zahra Abtahian; Mohammad Rahdar; Arefeh Sadat Mirahmadian; Atousa Hakamifard

doi:10.1155/2022/8114388

Coinfection by Aspergillus and Mucoraceae Species in Two Cases of Acute Rhinosinusitis as a Complication of COVID-19

Case Rep Med. 2022 Mar 14:2022:8114388. doi: 10.1155/2022/8114388. eCollection 2022.

Authors

Payam Tabarsi¹, Somayeh Sharifynia¹, Mihan Pourabdollah Toutkaboni², Zahra Abtahian¹, Mohammad Rahdar³, Arefeh Sadat Mirahmadian³, Atousa Hakamifard³

Affiliations

¹ Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Acute invasive fungal rhinosinusitis (AIFR) is a life-threatening infection often found in immunocompromised patients. In the COVID-19 era, reports of AIFR have emerged, with high mortality and morbidity rate. This paper presents two cases of COVID-19 associated AIFR with the combined proven fungal etiology of Aspergillus flavus and Rhizopus arrhizus in case 1 and Aspergillus fumigatus and Rhizopus arrhizus in case 2. Both patients received liposomal amphotericin B then posaconazole combined with aggressive surgical debridement of necrotic tissues with a favorable clinical outcome. Mixed etiology AIFR can influence the outcome; hence, further studies are required upon this new threat.

Publication types

Case Reports