A Metastatic Intrahepatic Cholangiocarcinoma With HPCs Features: Report of a Case

Qiang Fu; Pan Liu; Shangkun Jin; Xu Zhang; Chuanjiang Liu; Mingxing Hu; Yuzhu Wang; Hongwei Zhang; Tao Qin

doi:10.3389/fonc.2022.829235

A Metastatic Intrahepatic Cholangiocarcinoma With HPCs Features: Report of a Case

Front Oncol. 2022 Mar 1:12:829235. doi: 10.3389/fonc.2022.829235. eCollection 2022.

Authors

Qiang Fu¹, Pan Liu¹, Shangkun Jin², Xu Zhang¹, Chuanjiang Liu¹, Mingxing Hu^{1

2}, Yuzhu Wang^{1

2}, Hongwei Zhang¹, Tao Qin¹

Affiliations

¹ Department of Hepato-Biliary-Pancreatic Surgery, Henan Provincial People's Hospital (People's Hospital of Zhengzhou University), Zhengzhou, China.
² Department of Hepato-Biliary-Pancreatic Surgery, People's Hospital of Henan University, Zhengzhou, China.

Abstract

Intrahepatic cholangiocarcinoma (ICC) is a highly lethal hepatobiliary neoplasm, which originates from the bile ducts proximal to the second-order division. ICC can be anatomically divided into two subtypes: the large duct type (mucin-production ICC, muc-ICC) and the small duct type (mixed-ICC) origins from hepatic progenitor cells (HPCs). The immunoreactivity of S100P and neural cell adhesion molecule (NCAM) are useful biomarkers to distinguish the two subtypes. In this study, we report a difficult-to-diagnose case of metastatic retroperitoneal tumor of occult hepatolithiasis-associated ICC. Besides, this case was both positive for S100P and NCAM, considered as a rare muc-ICC with the HPCs features. Tumor whole exome sequencing detection results by Genetron (China) revealed that there were 41 gene mutations in this patient. The SMAD4-p.His530ThrfsTer47 and KRAS-p.Gly12Val mutation might promote the occurrence and distant metastasis of the tumor.

Keywords: gene mutation; hepatic progenitor cells; intrahepatic cholangiocarcinoma; mixed ICC; muc-ICC.

Publication types

Case Reports