Copper-Catalyzed Regiodivergent and Enantioselective Hydrosilylation of Allenes

J Am Chem Soc. 2022 Mar 30;144(12):5535-5542. doi: 10.1021/jacs.2c00260. Epub 2022 Mar 17.

Abstract

A copper-catalyzed regiodivergent hydrosilylation of a wide range of simple allenes is reported. Linear and branched allylsilanes were formed by judicious choice of solvents. Furthermore, branched allylsilanes were obtained with high enantioselectivity (up to 97% enantiomeric excess) with the aid of a C2-symmetric bisphosphine ligand in the unprecedented asymmetric allene hydrosilylation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkadienes*
  • Catalysis
  • Copper*
  • Stereoisomerism

Substances

  • Alkadienes
  • propadiene
  • Copper