Amphipathic poly-β-peptides for intracellular protein delivery

Qianyi Ren; Qi Chen; Lanfang Ren; Chuntao Cao; Runhui Liu; Yiyun Cheng

doi:10.1039/d2cc00453d

Amphipathic poly-β-peptides for intracellular protein delivery

Chem Commun (Camb). 2022 Mar 31;58(27):4320-4323. doi: 10.1039/d2cc00453d.

Authors

Qianyi Ren¹, Qi Chen², Lanfang Ren¹, Chuntao Cao², Runhui Liu², Yiyun Cheng¹

Affiliations

¹ Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, 200241, P. R. China. yycheng@mail.ustc.edu.cn.
² State Key Laboratory of Bioreactor Engineering, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

PMID: 35293911
DOI: 10.1039/d2cc00453d

Abstract

A series of amphipathic poly-β-peptides are designed for intracellular protein delivery. The poly-β-peptides with higher molecular weight and hydrophobic contents exhibit higher protein loading and superior delivery efficiency. The lead material efficiently delivers proteins into cells with reserved bioactivity.

MeSH terms

Hydrophobic and Hydrophilic Interactions
Peptides* / chemistry
Poly A
Proteins*

Substances

Peptides
Proteins
Poly A