The fabrication of an innovative extremely sensitive nano green carbon paste electrode amended with the nanocomposite CuO/Y for electrochemical quantification of amprolium in sheep meat and liver samples

Elsayed Elgazzar; Ragab A M Said; Adham A El-Zomrawy; Ashraf M Ashmawy; Ahmed M Abdel-Raoof; Wageha A Mostafa; Hany Ibrahim; Abdul-Aziz M M El-Attar

doi:10.1016/j.foodchem.2022.132668

The fabrication of an innovative extremely sensitive nano green carbon paste electrode amended with the nanocomposite CuO/Y for electrochemical quantification of amprolium in sheep meat and liver samples

Food Chem. 2022 Aug 15:385:132668. doi: 10.1016/j.foodchem.2022.132668. Epub 2022 Mar 9.

Authors

Elsayed Elgazzar¹, Ragab A M Said², Adham A El-Zomrawy³, Ashraf M Ashmawy³, Ahmed M Abdel-Raoof⁴, Wageha A Mostafa⁵, Hany Ibrahim⁶, Abdul-Aziz M M El-Attar⁷

Affiliations

¹ Department of Physics, Faculty of Science, Suez Canal, University, Ismailia, Egypt.
² Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, 3 Cairo, Belbeis, Desert Road, Cairo, Egypt.
³ Chemistry Department, Faculty of Science (boys), Al-Azhar University, 11884, Egypt.
⁴ Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt. Electronic address: Ahmedmeetyazeed79@Azhar.edu.eg.
⁵ Entomolgy Section, Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt.
⁶ Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, Cairo 11829, Egypt.
⁷ Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, 11751, Nasr City, Cairo, Egypt. Electronic address: Abdul.azizalattar@azhar.edu.eg.

PMID: 35290954
DOI: 10.1016/j.foodchem.2022.132668

Abstract

In this work, carbon paste electrode (CPE) and modified CPE with copper oxide or copper yttrium oxide were prepared for determining amprolium hydrochloride (AMP) by differential pulse voltammetry. AMP has an antiprotozoal activity for treating coccidiosis in poultry; their retaining- in sheep meat and livers- induces adversative effects for the customer. XRD pattern was employed to define the fabricated nanostructured materials; the elemental composition of the nanocomposite was examined using EDX spectra. Over a pH ranging from 2 to 8, the oxidation process of AMP was studied using phosphate buffer. The scan rates were studied over a wide range (20 to 140 mV s^-1) using cyclic voltammetry. The developed sensor shows a wide linear range (1.0 × 10^-8-1.0 × 10^-3 M) with a detection limit of 2.32 × 10^-9 M. This method can quantify AMP in pharmaceutical form, sheep meat, and liver samples.

Keywords: Amprolium hydrochloride; Copper yttrium oxide; Differential pulse voltammetry; Nanoparticles.

MeSH terms

Adenosine Monophosphate
Amprolium
Animals
Carbon / chemistry
Copper* / chemistry
Electrochemical Techniques / methods
Electrodes
Limit of Detection
Liver
Meat
Nanocomposites*
Sheep

Substances

Adenosine Monophosphate
Carbon
Copper
Amprolium
cupric oxide