Efficient photothermal and photodynamic synergistic antibacterial therapy of Cu7S4 nanosheets regulated by facet engineering

Shudi Mo; Yan Zhao; Jinghong Wen; Jingyu Sun; Ze Zhang; Qilin Yu; Guichang Wang; Xue Chen; Mingyang Liu

doi:10.1016/j.jhazmat.2022.128662

Efficient photothermal and photodynamic synergistic antibacterial therapy of Cu₇S₄ nanosheets regulated by facet engineering

J Hazard Mater. 2022 Jun 15:432:128662. doi: 10.1016/j.jhazmat.2022.128662. Epub 2022 Mar 12.

Authors

Shudi Mo¹, Yan Zhao², Jinghong Wen³, Jingyu Sun¹, Ze Zhang¹, Qilin Yu⁴, Guichang Wang⁵, Xue Chen⁶, Mingyang Liu⁷

Affiliations

¹ Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, PR China.
² Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, PR China.
³ Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) and the Tianjin key Lab and Molecule-based Material Chemistry, College of Chemistry, Nankai University, Tianjin 300071, PR China.
⁴ Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, PR China. Electronic address: yuqilin@mail.nankai.edu.cn.
⁵ Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) and the Tianjin key Lab and Molecule-based Material Chemistry, College of Chemistry, Nankai University, Tianjin 300071, PR China. Electronic address: wangguichang@nankai.edu.cn.
⁶ College of Environmental Science and Engineering, Shandong University, Qingdao 266237, PR China. Electronic address: xuechen@sdu.edu.cn.
⁷ Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, PR China; Department of Civil and Environmental Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA. Electronic address: evanlmy@163.com.

PMID: 35290893
DOI: 10.1016/j.jhazmat.2022.128662

Abstract

The surface arrangements of nanomaterials can regulate their electronic structure, which will tune physicochemical properties of materials to various applications. In this study, two Cu₇S₄ nanosheets with (304) and (224) exposed facets were synthesized, respectively, and their antibacterial activity of different facets for replacing antibiotics to solve seriously drug-resistant bacteria were further measured. Experimental and theoretical computation results unveiled that Cu₇S₄ with (224) exposed facet exhibited excellent antibacterial activity through synergetic photodynamic and photothermal therapy against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli and drug-resistant Pseudomonas aeruginosa under near-infrared light (808 nm) irradiation. Furthermore, the antibacterial agents strongly inhibit mouse skin infection by drug-resistant Pseudomonas aeruginosa cells. The findings provide an efficient antibacterial strategy and might advance the method of designing and producing highly effective antibacterial nanomaterials through facet engineering.

Keywords: Antibacterial activity; Cu(7)S(4) nanosheets; Facet dependence; Photodynamic; Photothermal therapy; Theoretical computation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Bacterial Agents / chemistry
Bacteria
Infrared Rays
Mice
Nanostructures*
Photochemotherapy*

Substances

Anti-Bacterial Agents