Enzymatic approaches to site-selective oxidation of quinoline and derivatives

Zhongqiang Wang; Ling Zhao; Xueqing Mou; Yongzheng Chen

doi:10.1039/d2ob00200k

Enzymatic approaches to site-selective oxidation of quinoline and derivatives

Org Biomol Chem. 2022 Mar 30;20(13):2580-2600. doi: 10.1039/d2ob00200k.

Authors

Zhongqiang Wang^{1

2}, Ling Zhao^{1

2}, Xueqing Mou^{1

2}, Yongzheng Chen^{1

2}

Affiliations

¹ Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Generic Drug Research Center of Guizhou Province, Green Pharmaceuticals Engineering Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, 563000 Zunyi, People's Republic of China. yzchen@zmu.edu.cn.
² Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, 563000 Zunyi, People's Republic of China.

PMID: 35290426
DOI: 10.1039/d2ob00200k

Abstract

Enzyme-mediated oxidation has been a green and efficient strategy for preparation of derivative chemicals from quinoline and its structural analogues. Herein, we report the progress made to date in enzymatic methods to oxidation of the pyridine moieties of quinoline and its structural analogues 1,2,3,4-tetrahydroquinoline, isoquinoline and 1,2,3,4-tetrahydroisoquinoline, including whole cell- and isolated enzyme-based transformations. In addition, methods to tune the site selectivity of the course of enzymatic transformation are also addressed, in particular the protein engineering approaches.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Oxidation-Reduction
Quinolines* / chemistry

Substances

Quinolines
quinoline