Fungal exopolysaccharides: Properties, sources, modifications, and biomedical applications

Masoud Hamidi; Oseweuba Valentine Okoro; Peiman Brouki Milan; Mohammad Reza Khalili; Hadi Samadian; Lei Nie; Amin Shavandi

doi:10.1016/j.carbpol.2022.119152

Fungal exopolysaccharides: Properties, sources, modifications, and biomedical applications

Carbohydr Polym. 2022 May 15:284:119152. doi: 10.1016/j.carbpol.2022.119152. Epub 2022 Jan 21.

Authors

Masoud Hamidi¹, Oseweuba Valentine Okoro², Peiman Brouki Milan³, Mohammad Reza Khalili⁴, Hadi Samadian⁵, Lei Nie⁶, Amin Shavandi⁷

Affiliations

¹ Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium; Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, Iran.
² Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium.
³ Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
⁴ Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
⁵ Department of Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address: H30samadiyan@gmail.com.
⁶ College of Life Sciences, Xinyang Normal University, Xinyang 464000, China. Electronic address: nielei@xynu.edu.cn.
⁷ Université libre de Bruxelles (ULB), École polytechnique de Bruxelles, 3BIO-BioMatter, Avenue F.D. Roosevelt, 50 - CP 165/61, 1050 Brussels, Belgium. Electronic address: amin.shavandi@ulb.be.

PMID: 35287892
DOI: 10.1016/j.carbpol.2022.119152

Abstract

Fungal exopolysaccharides (EPSs) are natural biopolymers with diverse potential applications in the biomedical, packaging, cosmetic, and food industries. Fungal EPSs are easy to extract and purify polysaccharides that are biodegradable, biocompatible, with low immunogenicity, bioadhesion ability, antibacterial activity, and contain different reactive groups such as hydroxyl, carboxyl, and amine for chemical modifications. Despite fast progress in identifying and characterization fungal EPSs for biomedical applications, i.e., wound healing, drug, and gene delivery, only a few products have been commercialized based on fungal EPSs. This review critically discusses potential biomedical applications of fungi sourced EPSs in tissue engineering (TE), drug and gene delivery.

Keywords: Chitosan (PubChem CID: 71853); Drug delivery; Exopolysaccharide; Gene delivery; Lentinan (PubChem CID: 37723); Pullulan (PubChem CID: 439586); Schizophyllan (PubChem CID: 24777); Scleroglucan (PubChem CID: 131750928); Tissue engineering.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Chitosan* / chemistry
Fungi
Tissue Engineering
Wound Healing

Substances

Anti-Bacterial Agents
Chitosan