A case of therapy-related acute lymphoblastic leukemia following the treatment of acute myeloid leukemia

Sufana Shikdar; Yuan Ying; Mohamad Khawandanah

doi:10.1016/j.lrr.2022.100297

A case of therapy-related acute lymphoblastic leukemia following the treatment of acute myeloid leukemia

Leuk Res Rep. 2022 Mar 1:17:100297. doi: 10.1016/j.lrr.2022.100297. eCollection 2022.

Authors

Sufana Shikdar¹, Yuan Ying¹, Mohamad Khawandanah¹

Affiliation

¹ Department of Hematology/Oncology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States.

Abstract

Therapy-related acute lymphoblastic leukemia represents a distinct entity associated with inferior survival compared with de novo acute lymphoblastic leukemia. It consists of a subset of patients who have had exposure to chemotherapy or radiation for a previous malignancy. Here, we describe a case of acute myeloid leukemia who later developed precursor B cell acute lymphoblastic leukemia and discuss the current relevant literature. Our case highlights the importance of classifying therapy-related acute lymphoblastic leukemia as a separate as entity based on its biologic and clinical features.

Keywords: Acute myeloid leukemia; Secondary leukemia; Therapy-related acute lymphoblastic leukemia.

Publication types

Case Reports