Transcription and Post-translational Regulation of Autophagy in Insects

Rongsong Li; Yang Xiao; Kang Li; Ling Tian

doi:10.3389/fphys.2022.825202

Transcription and Post-translational Regulation of Autophagy in Insects

Front Physiol. 2022 Feb 25:13:825202. doi: 10.3389/fphys.2022.825202. eCollection 2022.

Authors

Rongsong Li^{1

2

3}, Yang Xiao⁴, Kang Li^{2

5}, Ling Tian^{1

2

3}

Affiliations

¹ Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
² Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
³ Guangdong Provincial Sericulture and Mulberry Engineering Research Center, College of Animal Science, South China Agricultural University, Guangzhou, China.
⁴ Department of Sericulture and Southern Medicine Resources Utilization, The Sericultural and Agri-Food Research Institute of the Guangdong Academy of Agricultural Sciences, Guangzhou, China.
⁵ Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China.

Abstract

Autophagy attracts great attention, and numerous progresses have been obtained in the last two decades. Autophagy is implicated in mammalian neurodegenerative diseases, tumorigenesis, as well as development in insects. The regulatory mechanism of autophagy is well documented in yeast and mammals, whereas it is not fully illustrated in insects. Drosophila melanogaster and Bombyx mori are the two well-studied insects for autophagy, and several insect-mammalian evolutionarily conserved or insect-specific mechanisms in regulating autophagy are reported. In this review, we summarize the most recent studies of autophagy regulated at both transcriptional and post-translational levels by insect hormone in cooperation with other signals, such as nutrient, which will provide a reference and deep thinking for studies on autophagy in insects.

Keywords: autophagy; insect hormone; nutrient signal; post-translational modification; transcription.